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MARCH9 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH9 induces internalization of several membrane glycoproteins and directs them to the endosomal compartment.
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Protein Aliases: 9-Mar; E3 ubiquitin-protein ligase MARCH9; E3 ubiquitin-protein ligase MARCHF9; MARCH-IX; membrane associated ring finger 9; membrane-associated ring finger (C3HC4) 9; membrane-associated ring finger 9; Membrane-associated RING finger protein 9; Membrane-associated RING-CH protein IX; RING finger protein 179; RING-type E3 ubiquitin transferase MARCHF9
Gene Aliases: AI608492; BC019560; MARCH-IX; MARCH9; MARCHF9; RNF179
UniProt ID: (Human) Q86YJ5, (Mouse) Q3TZ87
Entrez Gene ID: (Human) 92979, (Mouse) 216438, (Rat) 679272
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