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Immunofluorescence staining of mixed neuron/glial cultures with anti-MARCKS antibody (PA1-10021) (Red) and anti-MAP2 antibody (PA1-10005) (green). Note that the MARCKS antibody stains vesicular structures both in the glial cells and in the dendrites of the neurons, which are strongly stained with the MAP2 antibody.
|Tested species reactivity||Horse, Mouse, Pig, Rat, Human, Bovine, Chicken|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Full-length recombinant human MARCKS|
|Storage buffer||whole serum|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:20,000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MARCKS is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
80K protein; ACAMP-81; KINC; Macs; Myristoylated alanine rich C Kinase substrate; myristoylated alanine-rich C kinase substrate (MARCKS); myristoylated alanine-rich C-kinase substrate; Myristoylated alanine-rich protein kinase C substrate; myristoylated alanine-rich protein kinase C substrate (MARCKS, 80K-L); phosphomyristin; protein kinase C substrate 80 kDa protein; protein kinase C substrate, 80 kDa protein, light chain
80K-L; BOS_9607; KINC; MACS; PKCSL; PRKCSL
Signal transduction Intracellular signaling cascade Calcium mediated signaling Oncogenesis Tumor suppressor Developmental processes Ectoderm development Neurogenesis Cell structure and motility Cell motility