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Proteintech
MARK1 Polyclonal Antibody
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Product Details
21552-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MARK1 Fusion Protein Ag16225 (506-611 aa encoded by BC113869)
Conjugate
Form
Liquid
Concentration
0.36 mg/mL
Amount
54 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: VCERTTDRY VALQNGKDSS LTEMSVSSIS SAGSSVASAV PSARPRHQKS MSTSGHPIKV TLPTIKDGSE AYRPGTTQRV PAASPSAHSI STATPDRTRF PRGSSSR (506-611 aa encoded by BC113869 )
Target Information
MARK1 (MARK) is a serine/threonine kinase which is involved in cytoskeletal organization and biogenesis. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. MARK1 is involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ELKL motif serine-threonine protein kinase 3; ELKL motif serine/threonine-protein kinase 3; MAP/microtubule affinity-regulating kinase 1; mark1; mark1 {ECO:0000312|RGD:619882}; Par-1c; PAR1 homolog c; Serine/threonine-protein kinase MARK1; unnamed protein product
Gene Aliases: AW491150; B930025N23Rik; Emk3; KIAA1477; MARK; MARK1; mKIAA1477; mPar-1c; Par-1c; Par1c
UniProt ID: (Human) Q9P0L2, (Mouse) Q8VHJ5, (Rat) O08678
Entrez Gene ID: (Human) 4139, (Mouse) 226778, (Rat) 117016
nucleotide binding
magnesium ion binding
phosphatidylserine binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
phosphatidylinositol-4,5-bisphosphate binding
lipid binding
kinase activity
transferase activity
metal ion binding
tau protein binding
tau-protein kinase activity
phosphatidic acid binding
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
microtubule cytoskeleton organization
neuron migration
protein phosphorylation
cytoskeleton organization
positive regulation of gene expression
negative regulation of gene expression
negative regulation of epithelial to mesenchymal transition
regulation of neuron projection development
Wnt signaling pathway
intracellular signal transduction
regulation of dendrite development
establishment of mitochondrion localization
regulation of postsynapse assembly
phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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