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Proteintech
MARK2 Polyclonal Antibody
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Product Details
15492-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MARK2 Fusion Protein Ag7884 (10-372 aa encoded by BC008771)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Amount
34.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LNERDTEQP TLGHLDSKPS SKSNMIRGRN SATSADEQPH IGNYRLLKTI GKGNFAKVKL ARHILTGKEV AVKIIDKTQL NSSSLQKLFR EVRIMKVLNH PNIVKLFEVI ETEKTLYLVM EYASGGEVFD YLVAHGRMKE KEARAKFRQI VSAVQYCHQK FIVHRDLKAE NLLLDADMNI KIADFGFSNE FTFGNKLDTF CGSPPYAAPE LFQGKKYDGP EVDVWSLGVI LYTLVSGSLP FDGQNLKELR ERVLRGKYRI PFYMSTDCEN LLKKFLILNP SKRGTLEQIM KDRWMNVGHE DDELKPYVEP LPDYKDPRRT ELMVSMGYTR EEIQDSLVGQ RYNEVMATYL LLGYKSSELE GDTI (10-372 aa encoded by BC008771)
Target Information
MARK2 is a serine/threonine protein kinase involved in the control of cell polarity and microtubule stability. Several cDNA clones have been isolated that encoded two isoforms of the human ser/thr protein kinase EMK1. These isoforms were characterized by the presence of a 162-bp alternative exon that gave rise to two forms, one containing the exon and the other one lacking it. Both forms were found to be coexpressed in a number of selected cell lines and tissue samples. The human EMK1 was shown to be encoded by a single mRNA ubiquitously expressed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ELKL motif kinase; ELKL motif kinase 1; EMK-1; EMK1; MAP/microtubule affinity-regulating kinase 2; mark2 {ECO:0000312|RGD:708483}; MGC99619; OTTHUMP00000218338; OTTHUMP00000218339; OTTHUMP00000218340; OTTHUMP00000218343; Par-1b; PAR1 homolog; PAR1 homolog b; Ser/Thr protein kinase PAR-1B; serine/threonine kinase; serine/threonine protein kinase EMK; Serine/threonine-protein kinase MARK2; testicular tissue protein Li 117; unnamed protein product
Gene Aliases: Emk; EMK-1; EMK1; MARK2; PAR-1; Par-1b; Par1b
UniProt ID: (Human) Q7KZI7, (Rat) O08679, (Mouse) Q05512
Entrez Gene ID: (Human) 2011, (Rat) 60328, (Mouse) 13728
nucleotide binding
magnesium ion binding
RNA binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
lipid binding
kinase activity
transferase activity
protein kinase activator activity
cadherin binding
metal ion binding
tau protein binding
tau-protein kinase activity
protein serine kinase activity
poly(A) RNA binding
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
microtubule cytoskeleton organization
mitophagy
neuron migration
protein phosphorylation
positive regulation of neuron projection development
Wnt signaling pathway
establishment of cell polarity
cell differentiation
intracellular signal transduction
establishment or maintenance of epithelial cell apical/basal polarity
protein autophosphorylation
regulation of axonogenesis
regulation of cytoskeleton organization
mitochondrion localization
axon development
regulation of microtubule cytoskeleton organization
establishment or maintenance of cell polarity regulating cell shape
regulation of neurofibrillary tangle assembly
multicellular organism development
phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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