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Invitrogen
MARVELD2 Polyclonal Antibody
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FIGURE: 1 / 1
MARVELD2 Antibody (PA5-97168) in WB
Western blot analysis of MARVELD2 in extracts of SH-SY5Y cells. Samples were incubated with MARVELD2 Polyclonal antibody (Product # PA5-97168) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-97168
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human MARVELD2 (NP_0010336922)
Conjugate
Form
Liquid
Concentration
0.51 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: ELLLGAGVFA CVTAYIHKDS EWYNLFGYSQ PYGMGGVGGL GSMYGGYYYT GPKTPFVLVV AGLAWITTII ILVLGMSMYY RTILLDSNWW PLTEFGINVA L; Positive Samples: SH-SY5Y; Cellular Location: Cell junction, Cell membrane, Multi-pass membrane protein, tight junction
Target Information
Tight junctions form an important barrier of paracellular transport in epithelial cells. Sealing of two adjacent cells at bicellular tight junctions, a point where three adjacent cells are in contact with each other. Tricellulin is the first protein identified that specifically concentrates in tricellular tight junctions. This protein has four membrane spanning domains, similarly to claudins. Tricellulin expression is high in epithelium-derived tissues, such as small intestine, kidney and lung. Functional evidence for the role of tricellulin in tight junction formation comes from siRNA studies, where suppression of its expression leads to compromised epithelial barrier and tight junction formation. Loss of function in tricellulin mutants missing all or most of a conserved region in the cytosolic domain which binds to the cytosolic scaffolding protein ZO-1, indicate that interaction with other known tight junction proteins plays an important role for the function of tricellulin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MARVEL (membrane-associating) domain containing 2; MARVEL domain-containing protein 2; Tricellulin
Gene Aliases: BC003296; DFNB49; MARVD2; MARVELD2; MRVLDC2; TRIC; Trica; Tricb; Tricc
UniProt ID: (Human) Q8N4S9, (Mouse) Q3UZP0
Entrez Gene ID: (Human) 153562, (Mouse) 218518, (Rat) 365657
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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