The proto-oncogene MAS1 is a G protein-coupled receptor located on the plasma membrane. In transfected NIH/3T3 cells, MAS1 has a weak focus-inducing activity. MAS1 is an antagonist of the AT1 receptor (Angiotensin II type 1 receptor), inhibiting the actions of Angiotensin II. MAS1L (MAS1-like), also known as MAS-L or MRG (Mas-related G-protein coupled receptor MRG), is a 378 amino acid multi-pass membrane protein that belongs to the G-protein coupled receptor 1 (GPCR) family. MAS1 related proteins are thought to regulate nociceptor function and development, including the sensation or modulation of pain.
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Protein Aliases: DAAP-341G9.4; MAS-R; mas-related G protein-coupled MRG; Mas-related G-protein coupled receptor MRG; MAS1 oncogene-like; MAS1-like; MGC119987; Mrg and gpcr
Gene Aliases: dJ994E9.2; MAS-L; MAS1L; MRG
UniProt ID: (Human) P35410
Entrez Gene ID: (Human) 116511
Molecular Function: G-protein coupled receptor