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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||human partial MASTL recombinant protein.|
|Purification||Antigen affinity chromatography|
|Contains||0.09% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||1:10-1:50|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
GREATWALL; greatwall kinase homolog; greatwall protein kinase; GWL; hGWL; MAST-L; microtubule-associated serine/threonine-protein kinase-like; RP11-85G18.2; serine/threonine-protein kinase greatwall; THC2
GREATWALL; GW; GWL; MAST-L; MASTL; THC2