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Invitrogen
ATOH1 Polyclonal Antibody
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FIGURE: 1 / 5
ATOH1 Antibody (PA5-29392) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of MATH1 was performed in DIV9 rat E18 primary hippocampal neuron cells fixed in 4% paraformaldehyde at RT for 15 min. Green: MATH1 Polyclonal Antibody (Product # PA5-29392) diluted at 1:500. Red: beta Tubulin 3/ Tuj1, stained by beta Tubulin 3/ Tuj1 antibody. Blue: Fluoroshield with DAPI.
Product Details
PA5-29392
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human MATH1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1.42 mg/mL
Amount
142 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Predicted reactivity: Mouse (100%), Rat (100%), Chimpanzee (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The Drosophila atonal gene produces a protein with basic helix loop helix (bHLH) domains that plays an essential role in the development of the Drosophila nervous system. Mammalian atonal homolog 1 (MATH-1) is a helix-loop-helix (HLH) transcription factor that is structurally homologous to the product of the Drosophila proneural gene atonal. MATH-1, so known as Atoh1, Ath1 or HATH-1, is a 351 amino acid protein with an atonal-related basic HLH domain. In mice, expression of MATH-1 takes place by embryonic day 9. 5 and initially localizes to the cranial ganglions and the dorsal part of the central nervous system. Prominent expression of MATH-1 is in the dorsal part of the central nervous system but becomes restricted to the external granular layer of the cerebellum by day 18 and is undetectable in the adult nervous system. It is suggested that MATH-1 may play a role in the differentiation of subsets of neural cells by activating E box-dependent transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Atonal bHLH transcription factor 1; atonal homolog 1; atonal homolog bHLH transcription factor 1; basic helix-loop-helix family member a14; bHLHa14; Class A basic helix-loop-helix protein 14; H MATH-1; hATH1; Helix-loop-helix protein hATH-1; Helix-loop-helix protein mATH-1; mATH1; Protein atonal homolog 1; Transcription factor ATOH1
Gene Aliases: ATH1; ATOH1; BHLHA14; DFNA89; HATH1; MATH-1; Math1; RGD1565171
UniProt ID: (Human) Q92858, (Mouse) P48985
Entrez Gene ID: (Human) 474, (Mouse) 11921, (Rat) 500156
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
chromatin DNA binding
sequence-specific DNA binding
protein dimerization activity
E-box binding
sequence-specific double-stranded DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
protein binding
basic helix-loop-helix transcription factor
neuron migration
transcription from RNA polymerase II promoter
Notch signaling pathway
nervous system development
axon guidance
central nervous system development
brain development
sensory organ development
negative regulation of gliogenesis
central nervous system neuron differentiation
cerebral cortex development
cell differentiation
inner ear morphogenesis
auditory receptor cell differentiation
auditory receptor cell fate specification
auditory receptor cell fate determination
positive regulation of auditory receptor cell differentiation
regulation of neuron differentiation
positive regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
neuron fate commitment
system development
inner ear development
axon development
neuroblast migration
epithelial cell apoptotic process
negative regulation of epithelial cell apoptotic process
positive regulation of inner ear receptor cell differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
neuron differentiation
negative regulation of apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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