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Invitrogen
MAdCAM1 Polyclonal Antibody
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FIGURE: 1 / 2
MAdCAM1 Antibody (PA5-116979) in IHC (P)
Immunohistochemistry analysis of MAdCAM1 in paraffin-embedded human appendix. Samples were incubated with MAdCAM1 Polyclonal antibody (Product # PA5-116979) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-116979
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide
Conjugate
Form
Liquid
Concentration
2.67 mg/mL
Amount
267 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: SW480, SH-SY5Y, Jurkat, A-549, mouse spleen, rat spleen
Target Information
The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hMAdCAM-1; MAdCAM-1; MADCAM1; mMAdCAM-1; Mucosal addressin cell adhesion molecule 1; rMAdCAM-1
Gene Aliases: AV211525; MACAM1; MADCAM1
UniProt ID: (Human) Q13477, (Rat) O70540
Entrez Gene ID: (Human) 8174, (Rat) 54266, (Mouse) 17123
positive regulation of leukocyte migration
cell adhesion
cell-matrix adhesion
integrin-mediated signaling pathway
aging
keratinocyte differentiation
heterotypic cell-cell adhesion
receptor clustering
leukocyte migration
leukocyte tethering or rolling
immune response
signal transduction
positive regulation of lymphocyte migration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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