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Proteintech
MBL2 Polyclonal Antibody
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Product Details
24207-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MBL2 Fusion Protein Ag21508 (21-248 aa encoded by BC069338)
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Amount
46.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: ETVTCEDAQ KTCPAVIACS SPGINGFPGK DGRDGTKGEK GEPGQGLRGL QGPPGKLGPP GNPGPSGSPG PKGQKGDPGK SPDGDSSLAA SERKALQTEM ARIKKWLTFS LGKQVGNKFF LTNGEIMTFE KVKALCVKFQ ASVATPRNAA ENGAIQNLIK EEAFLGITDE KTEGQFVDLT GNRLTYTNWN EGEPNNAGSD EDCVLLLKNG QWNDVPCSTS HLAVCEFPI (21-248 aa encoded by BC069338)
Target Information
MBL2 is a calcium-dependent lectin involved in innate immune defense. It binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. It also binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. MBL2 may bind DNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: activates complement system; Collectin-1; Collectin1; mannan-binding lectin; Mannan-binding protein; Mannose-binding lectin; mannose-binding lectin (protein C) 2, soluble (opsonic defect); mannose-binding lectin 2, soluble (opsonic defect); Mannose-binding protein C; MBP-C; MBP1; MBPC; MGC116832; MGC116833
Gene Aliases: COLEC1; HSMBPC; MBL; MBL2; MBL2D; MBP; MBP-C; MBP1; MBPD
UniProt ID: (Human) P11226
Entrez Gene ID: (Human) 4153
complement activation, lectin pathway
activation of membrane attack complex
immune system process
cell surface pattern recognition receptor signaling pathway
proteolysis
acute-phase response
complement activation
complement activation, classical pathway
response to oxidative stress
opsonization
zymogen activation
killing of cells of other organism
defense response to bacterium
surfactant homeostasis
innate immune response
negative regulation of viral process
positive regulation of phagocytosis
defense response to Gram-positive bacterium
protein maturation
killing by host of symbiont cells
antiviral innate immune response
positive regulation of opsonization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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