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Invitrogen
MBL2 Polyclonal Antibody
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Product Details
PA5-46920
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse MBL-2 Glu19-Asp244
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In sandwich ELISAs, less than 0.1% cross-reactivity with recombinant mouse MBL-1 and recombinant human MBL is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
MBL2 is a calcium-dependent lectin involved in innate immune defense. It binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. It also binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. MBL2 may bind DNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Collectin1; Mannan-binding protein; mannose binding lectin (C); mannose binding lectin, liver (C); Mannose-binding protein C; MBP-C; MBPC; MGC116832; MGC116833; RA-reactive factor P28A subunit; RARF/P28A
Gene Aliases: L-MBP; MBL; MBL-C; Mbl2; MBP-C
UniProt ID: (Mouse) P41317
Entrez Gene ID: (Mouse) 17195
complement activation, lectin pathway
immune system process
complement activation, classical pathway
negative regulation of growth of symbiont in host
innate immune response
negative regulation of viral process
positive regulation of phagocytosis
defense response to Gram-positive bacterium
killing by host of symbiont cells
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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