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Invitrogen
MBP Polyclonal Antibody
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FIGURE: 1 / 3
MBP Antibody (PA1-46447) in WB
Western blot analysis of MBP in Human Brain lysate (0.5 mg/mL). Samples were incubated with MBP polyclonal antibody (Product # PA1-46447). Simple Western lane view shows a specific band for MBP. This experiment was performed under reducing conditions using the 12-230 kDa separation system.
Product Details
PA1-46447
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Residues 49-62 of Isoforms 5 and 6 of the human protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The PA1-46447 immunogen corresponds to residues 49-62 of Isoforms 5 and 6 of the human protein.
The immunogen corresponds to Isoform 1 between amino acids 182-195 of the 33 kDa isoform.
This antibody also detects mouse and rat MBP protein.Suggested positive control: normal human brain lysate.
Target Information
The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 17.3K myelin basic protein; golli mbp; Golli-Mbp; myelin basic protein; Golli-Mbp; myelin basic protein; myelin basic protein S; MBP; MBP S; MGC99675; Myelin A1 protein; Myelin basic protein; myelin basic protein Golli-mbp; myelin basic protein S; myelin deficient; Myelin membrane encephalitogenic protein; shiverer; unnamed protein product
Gene Aliases: C76307; golli-mbp; Hmbpr; MBP; Mbps; mld; R75289; Shi
UniProt ID: (Human) P02686, (Rat) Q505J1, (Mouse) P04370
Entrez Gene ID: (Human) 4155, (Rat) 24547, (Mouse) 17196
MAPK cascade
immune response
chemical synaptic transmission
central nervous system development
sensory perception of sound
axon ensheathment
response to toxic substance
substantia nigra development
positive regulation of interleukin-6 production
negative regulation of heterotypic cell-cell adhesion
maintenance of blood-brain barrier
myelination
membrane organization
positive regulation of metalloendopeptidase activity
positive regulation of chemokine (C-X-C motif) ligand 2 production
aging
response to progesterone
response to tumor necrosis factor
response to mercury ion
negative regulation of axonogenesis
response to fatty acid
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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