The PA1-46447 immunogen corresponds to residues 49-62 of Isoforms 5 and 6 of the human protein.
The immunogen corresponds to Isoform 1 between amino acids 182-195 of the 33 kDa isoform.
This antibody also detects mouse and rat MBP protein.Suggested positive control: normal human brain lysate.
Myelin Basic Protein (MBP) functions in the nervous system in myelination and is expressed in oligodendrocytes following differentiation. There are numerous isoforms generated by differential splicing events and post-translational modifications that have specialized functions. These functions include participation in signaling pathways prior to myelination, myelination or the re-myelination process following neural injury.
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Protein Aliases: Golli-Mbp; myelin basic protein; Golli-Mbp; myelin basic protein; myelin basic protein S; MBP; MBP S; MGC99675; Myelin A1 protein; Myelin basic protein; myelin basic protein Golli-mbp; myelin basic protein S; myelin deficient; Myelin membrane encephalitogenic protein; shiverer
Gene Aliases: C76307; golli-mbp; Hmbpr; MBP; Mbps; mld; R75289; Shi