MC1R, a Melanocortin Receptor, mediates the effects of melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). MSH and its receptor, MC1R, are key regulators of melanogenesis. They control the relative proportions of red pheomelanin and black photoprotective eumelanin in the skin by increasing the production of eumelanin. Non-functional, truncated forms of the receptor lead to lighter coat color in animals. In contrast, constitutively active receptors lead to darker color.
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Protein Aliases: alpha melanocyte stimulating hormone receptor; extension recessive yellow; MC1 receptor; MC1-R; melanocortin 1 receptor; melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor); Melanocortin receptor 1; melanocortin-1 receptor; Melanocyte-stimulating hormone receptor; melanotropin receptor; MSH-R; tobacco darkening
Gene Aliases: CMM5; e; MC1R; MSH-R; MSHR; Mshra; SHEP2; Tob
Molecular Function: G-protein coupled receptor