Invitrogen

MC1R Polyclonal Antibody

Product Details

Tested Applications

Dilution

Immunocytochemistry (ICC)

1:50-1:200

Immunofluorescence (IF)

1:50-1:200

Western Blot (WB)

1:500-1:1000

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host / Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to amino acids 300-350 of Human MC1R.

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

RRID

AB_2719070

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Target Information

MC1R, a Melanocortin Receptor, mediates the effects of melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). MSH and its receptor, MC1R, are key regulators of melanogenesis. They control the relative proportions of red pheomelanin and black photoprotective eumelanin in the skin by increasing the production of eumelanin. Non-functional, truncated forms of the receptor lead to lighter coat color in animals. In contrast, constitutively active receptors lead to darker color.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: alpha melanocyte stimulating hormone receptor; extension recessive yellow; MC1-R; MC1R; melanocortin 1 receptor; melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor); Melanocortin receptor 1; melanocortin-1 receptor; Melanocyte-stimulating hormone receptor; melanotropin receptor; MSH-R; MSHR; tobacco darkening

Gene Aliases: CMM5; e; MC1R; MSH-R; MSHR; Mshra; SHEP2; Tob

UniProt ID: (Human) Q01726, (Mouse) Q01727

Entrez Gene ID: (Human) 4157, (Rat) 102552838, (Mouse) 17199

Molecular Function: G-protein coupled receptor receptor