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MC1R Antibody (PA5-77487) in ICC/IF
Immunocytochemistry analysis of MC1R in paraffin-embedded human malignant melanoma cell lines. A) Samples were probed with MC1R polyclonal antibody (Product # PA5-77487) using a dilution of 1:200, and incubated with goat anti-rabbit-AlexaFluor-555. B) Live view cell image. C) Merged image of Panels A and B.
Product Details
PA5-77487
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide (C)HAQGIARLHKRQRPVH, corresponding to amino acid residues 217-232 of human MC1R
Conjugate
Unconjugated
Form
Lyophilized
Concentration
0.6 mg/mL
Storage conditions
-20°C
RRID
AB_2736121
Product Specific Information
Product is shipped at room temperature as a lyophilized powder and should be stored at -20 °C upon receipt. Reconstitution: add 50 µL of deionized water.
Target Information
MC1R, a Melanocortin Receptor, mediates the effects of melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). MSH and its receptor, MC1R, are key regulators of melanogenesis. They control the relative proportions of red pheomelanin and black photoprotective eumelanin in the skin by increasing the production of eumelanin. Non-functional, truncated forms of the receptor lead to lighter coat color in animals. In contrast, constitutively active receptors lead to darker color.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha melanocyte stimulating hormone receptor; MC1 receptor; MC1-R; melanocortin 1 receptor; melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor); Melanocortin receptor 1; Melanocyte-stimulating hormone receptor; melanotropin receptor; MSH-R
Gene Aliases: MC1R; MSHR
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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