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Fabgennix
MC4 Receptor Polyclonal Antibody, FITC
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Product Details
MC4R-FITC
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 10-60 on human MC4R protein.
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Expression of MC4R has been reported in brain. Unlike the other melanocortin receptors, MC4R is not expressed in adrenal cortex or in melanocytes. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MC4; MC4 receptor; MC4-R; Melanocortin receptor 4; mutant melanocortin-4 receptor; unnamed protein product
Gene Aliases: BMIQ20; Mc4-r; MC4R
UniProt ID: (Human) P32245, (Rat) P70596, (Mouse) P56450
Entrez Gene ID: (Human) 4160, (Rat) 25635, (Mouse) 17202
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
feeding behavior
regulation of metabolic process
insulin secretion
response to food
response to insulin
positive regulation of bone resorption
regulation of feeding behavior
regulation of eating behavior
response to melanocyte-stimulating hormone
diet induced thermogenesis
energy reserve metabolic process
positive regulation of cAMP biosynthetic process
negative regulation of feeding behavior
regulation of grooming behavior
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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