PA5-22081 targets MCD in ICC, IF, IHC (P), and WB applications and shows reactivity with Human and Mouse samples.
The PA5-22081 immunogen is a recombinant fragment corresponding to a region within amino acids 90 and 304 of (Uniprot ID#O95822).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
MCD catalyzes the breakdown of malonyl-CoA to acetyl-CoA and carbon dioxide. Malonyl-CoA is an intermediate in fatty acid biosynthesis, and also inhibits the transport of fatty acyl CoAs into mitochondria. Consequently, the encoded protein acts to increase the rate of fatty acid oxidation. It is found in mitochondria, peroxisomes, and the cytoplasm. Mutations in this gene result in malonyl-CoA decarboyxlase deficiency.
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Protein Aliases: malonyl coenzyme A decarboxylase; malonyl-CoA decarboxylase; Malonyl-CoA decarboxylase, mitochondrial; MCD; mitochondrial
Gene Aliases: AI324784; MCD; MLYCD