In IHC applications, antigen retrieval using a citrate buffer (pH 6.0) is recommended.
Percent identity with other species by BLAST analysis: Human (100%) Gorilla, Gibbon (94%) Monkey, Marmoset (89%) Panda, Pig (83%).
Melanin-concentrating hormone (MCH) is a 19 amino acid cyclic neuropeptide which is mainly expressed in the hypothalamus. MCH modulates feeding behavior, aggression, anxiety, arousal and reproductive function in mammals by controlling the release of luteinizing hormone (LH). The melanin-concentrating hormone receptor (MCHR, also designated SLC-1) is a glycosylated G-protein coupled receptor that migrates between 45-50 kDa on SDS-PAGE. MCHR mediates the effects of MCH through Gai and/or Gaq signaling and is expressed in several regions of the brain, including the cerebral cortex, amygdala, thalamus and hypothalamus. MCH and MCHR have also been implicated in stimulating leptin expression and secretion in adipocytes, which suggests that the melanin-concentrating hormone and its receptor may be potential targets for modulating obesity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: G protein-coupled receptor 145; G protein-coupled receptor slt; G-protein coupled receptor 145; GPRv17; MCH receptor 2; MCH-2R; MCH2; Mch2 receptor; melanin-concentrating hormone 2; Melanin-concentrating hormone receptor 2; SLT receptor
Gene Aliases: GPR145; GPRv17; MCH-2R; MCH-R2; MCH2; MCH2R; MCHR-2; MCHR2; SLT
UniProt ID: (Human) Q969V1
Entrez Gene ID: (Human) 84539