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Proteintech
MCM10 Polyclonal Antibody
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Product Details
12251-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MCM10 Fusion Protein Ag2899 (259-611 aa encoded by BC009108)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Amount
28.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MDLPTCGAR NLKQHLAKAS ASGIMGSPKP AIKSISASAL LKQQKQRMLE MRRRKSEEIQ KRFLQSSSEV ESPAVPSSSR QPPAQPPRTG SEFPRLEGAP ATMTPKLGRG VLEGDDVLFY DESPPPRPKL SALAEAKKLA AITKLRAKGQ VLTKTNPNSI KKKQKDPQDI LEVKERVEKN TMFSSQAEDE LEPARKKRRE QLAYLESEEF QKILKAKSKH TGILKEAEAE MQERYFEPLV KKEQMEEKMR NIREVKCRVV TCKTCAYTHF KLLETCVSEQ HEYHWHDGVK RFFKCPCGNR SISLDRLPNK HCSNCGLYKW ERDGMLKEKT GPKIGGETLL PRGEEHAKFL NSLK (259-611 aa encoded by B C009108)
Target Information
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: homolog of yeast MCM10; HsMCM10; MCM10 minichromosome maintenance deficient 10; MGC126776; minichromosome maintenance complex component 10; Protein MCM10 homolog; unnamed protein product
Gene Aliases: 2410041F14Rik; AU018508; C330019M07Rik; C79164; CNA43; DNA43; IMD80; MCM10; PRO2249
UniProt ID: (Human) Q7L590, (Mouse) Q8BMJ1
Entrez Gene ID: (Human) 55388, (Mouse) 70024
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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