Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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Immunogen sequence: PFEVNMEETI YQNYQRIRIQ ESPGKVAAGR LPRSKDAILL ADLVDSCKPG DEIELTGIYH NNYDGSLNTA NGFPVFATVI LANHVAKKDN KVAVGELTDE DVKMITSLSK DQQIGEKIFA SIAPSIYGHE DIKRGLALAL FGGEPKNPGG KHKVRGDINV LLCGDPGTAK SQFLKYIEKV SSRAIFTTGQ GASAVGLTAY VQRHPVSREW TLEAGALVLA DRGVCLIDEF DKMNDQDRTS IHEAMEQQSI SISKAGIVTS LQARCTVIAA ANPIGGRYDP SLTFSENVDL TEPIISRFDI LCVVRDTVDP VQDEMLARFV VGSHVRHHPS NKEEEGLANG S; Positive Samples: SW480, SH-SY5Y, Raji, A-549, HeLa, HL-60, Mouse thymus; Cellular Location: Nucleus
MCM2 (Mini chromosome maintenance protein 2) is involved in regulating DNA replication. MCM2 (also called CDCL1, mitotin and BM28), is a human nuclear protein that is crucial in the cell cycle, being involved in the onset of DNA replication and cell division. It is similar to members of the family of early S-phase proteins. MCM2 has been mapped to 3q21. From its localization, CDCL1 became a candidate for an oncogene affected by chromosomal breaks in acute myeloid leukemia (AML).
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Protein Aliases: cell devision cycle-like 1; cyclin-like 1; DNA replication licensing factor MCM2; MGC10606; mini chromosome maintenance deficient 2; minichromosome maintenance deficient 2 (mitotin); Minichromosome maintenance protein 2 homolog; Nuclear protein BM28
Gene Aliases: AA959861; AW476101; BM28; CCNL1; cdc19; CDCL1; D3S3194; DFNA70; KIAA0030; MCM2; Mcmd2; MITOTIN; mKIAA0030
UniProt ID: (Human) P49736, (Mouse) P97310
Entrez Gene ID: (Human) 4171, (Mouse) 17216
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