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Proteintech
MCM4 Polyclonal Antibody
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Product Details
13043-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MCM4 Fusion Protein Ag3703 (515-859 aa encoded by BC031061)
Conjugate
Form
Liquid
Concentration
0.17 mg/mL
Amount
25.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is a rabbit polyclonal antibody raised against the C-terminal 350 aa sequence of MCM4 protein.
Immunogen sequence: SKSQLLQYV YNLVPRGQYT SGKGSSAVGL TAYVMKDPET RQLVLQTGAL VLSDNGICCI DEFDKMNEST RSVLHEVMEQ QTLSIAKAGI ICQLNARTSV LAAANPIESQ WNPKKTTIEN IQLPHTLLSR FDLIFLMLDP QDEAYDRRLA HHLVALYYQS EEQAEEELLD MAVLKDYIAY AHSTIMPRLS EEASQALIEA YVDMRKIGSS RGMVSAYPRQ LESLIRLAEA HAKVRLSNKV EAIDVEEAKR LHREALKQSA TDPRTGIVDI SILTTGMSAT SRKRKEELAE ALKKLILSKG KTPALKYQQL FEDIRGQSDI AITKDMFEEA LRALADDDFL TVTGKT (515-859 aa encoded by BC031061)
Target Information
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CDC21 homolog; DNA replication licensing factor MCM4; homolog of S. pombe cell devision cycle 21; minichromosome maintenance deficient 4; P1-CDC21; unnamed protein product
Gene Aliases: CDC21; CDC54; hCdc21; IMD54; MCM4; NKCD; NKGCD; P1-CDC21
UniProt ID: (Human) P33991
Entrez Gene ID: (Human) 4173
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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