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This antibody is a rabbit polyclonal antibody raised against the C-terminal 350 aa sequence of MCM4 protein.
Immunogen sequence: SKSQLLQYV YNLVPRGQYT SGKGSSAVGL TAYVMKDPET RQLVLQTGAL VLSDNGICCI DEFDKMNEST RSVLHEVMEQ QTLSIAKAGI ICQLNARTSV LAAANPIESQ WNPKKTTIEN IQLPHTLLSR FDLIFLMLDP QDEAYDRRLA HHLVALYYQS EEQAEEELLD MAVLKDYIAY AHSTIMPRLS EEASQALIEA YVDMRKIGSS RGMVSAYPRQ LESLIRLAEA HAKVRLSNKV EAIDVEEAKR LHREALKQSA TDPRTGIVDI SILTTGMSAT SRKRKEELAE ALKKLILSKG KTPALKYQQL FEDIRGQSDI AITKDMFEEA LRALADDDFL TVTGKT (515-859 aa encoded by BC031061)
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CDC21 homolog; DNA replication licensing factor MCM4; homolog of S. pombe cell devision cycle 21; minichromosome maintenance deficient 4; P1-CDC21
Gene Aliases: CDC21; CDC54; hCdc21; MCM4; NKCD; NKGCD; P1-CDC21
UniProt ID: (Human) P33991
Entrez Gene ID: (Human) 4173
Molecular Function: DNA metabolism protein