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Bethyl Laboratories
MCM4 Polyclonal Antibody
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Product Details
IHC-00039
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 750 and 800 of human Minichromosome Maintenance 4.
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with X. laevis, Bovine, Horse, Rabbit, Guinea pig_10141, Orangutan, Monkey, Gorilla, Chimpanzee and Gray short-tailed opossum
Target Information
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CDC21 homolog; DNA replication licensing factor MCM4; homolog of S. pombe cell devision cycle 21; mini chromosome maintenance deficient 4 homolog; minichromosome maintenance deficient 4; P1-CDC21
Gene Aliases: 19G; AI325074; AU045576; CDC21; CDC54; hCdc21; mcdc21; MCM4; Mcmd4; mKIAA4003; NKCD; NKGCD; P1-CDC21
UniProt ID: (Human) P33991, (Mouse) P49717
Entrez Gene ID: (Human) 4173, (Mouse) 17217
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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