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The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CDC46 homolog; DNA replication licensing factor MCM5; MCM5 minichromosome maintenance deficient 5, cell division cycle 46; MGC5315; minichromosome maintenance deficient 5 (cell division cycle 46); minichromosome maintenance deficient 5, cell division cycle 46; P1-CDC46
Gene Aliases: AA617332; AI324988; AL033333; CDC46; MCM5; Mcmd5; P1-CDC46
UniProt ID: (Human) P33992, (Mouse) P49718
Entrez Gene ID: (Human) 4174, (Rat) 291885, (Mouse) 17218
Molecular Function:
DNA binding protein
DNA helicase
helicase
hydrolase
nucleic acid binding
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