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Immunogen sequence: SGLTVTLSK DSSSGDFALE AGALVLGDQG ICGIDEFDKM GNQHQALLEA MEQQSISLAK AGVVCSLPAR TSIIAAANPV GGHYNKAKTV SENLKMGSAL LSRFDLVFIL LDTPNEHHDH LLSEHVIAIR AGKQRTISSA TVARMNSQDS NTSVLEVVSE KPLSERLKVV PGETIDPIPH QLLRKYIGYA RQYVYPRLST EAARVLQDFY LELRKQSQRL NSSPITTRQL ESLIRLTEAR ARLELREEAT KEDAEDIVEI MKYSMLGTYS DEFGNLDFER SQHGSGMSNR STAKRFISAL NNVAERTYNN IFQFHQLRQI AKELNIQVAD FENFIGSLND QGYLLKKGPK VYQLQTM (380-735 aa encoded by BC008830 )
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described.
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Protein Aliases: DNA helicase MCM8; DNA replication licensing factor MCM8; MCM8 minichromosome maintenance deficient 8; MGC119522; MGC119523; MGC12866; MGC4816; Minichromosome maintenance 8; minichromosome maintenance complex component 8; minichromosome maintenance deficient 8; REC; REC homolog
Gene Aliases: 5730432L01Rik; C20orf154; dJ967N21.5; MCM8; POF10
UniProt ID: (Human) Q9UJA3, (Mouse) Q9CWV1, (Rat) D3ZVK1
Entrez Gene ID: (Human) 84515, (Mouse) 66634, (Rat) 296178
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