This Antibody was verified by Cell Treatment to ensure that the antibody binds to the antigen stated. View Details
Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds – the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody – recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets – a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
Monocyte chemotactic protein-1 (MCP-1) also known as CCL2 has a predicted molecular weight of ~11kDa; however, it may run at a higher molecular weight due to post translational modifications such as glycosylation. MCP-1 is a member of cytokine family and plays an important role in immunoregulation and inflammatory processes. MCP-1 is indicated in the etiology of several immune disorders. MCP-1 is also linked with tumor progression and related angiogenesis. MCP-1 displays selective chemotactic activity towards monocytes and basophils but not neutrophils or eosinophils. MCP-1 binds to chemokine receptors CCR2 and CCR4.
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Protein Aliases: C-C motif chemokine 2; C-C motif ligand 2; chemokine (C-C motif) ligand 2; GDCF-2; HC11; HSMCR30; MCAF; MCP-1; MCP1; Monocyte chemoattractant protein 1; monocyte chemoattractant protein-1; Monocyte chemotactic and activating factor; Monocyte chemotactic protein 1; Monocyte secretory protein JE; SCYA2; small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je); small inducible cytokine subfamily A (Cys-Cys), member 2; Small-inducible cytokine A2; SMC-CF
Gene Aliases: CCL2; GDCF-2; HC11; HSMCR30; MCAF; MCP-1; MCP1; SCYA2; SMC-CF
UniProt ID: (Human) P13500
Entrez Gene ID: (Human) 6347