PA1-24664 detects MCP2 from human samples.
PA1-24664 has been successfully used in neutralization, inhibition assays, and Western blot procedures. The ND50 is approximately 2-5 µg/mL in the presence of 0.4 µg/mL of human MCP2, using the human monocyte chemotaxis assay.
The PA1-24664 immunogen is purified, E. coli-derived, recombinant human MCP2.
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C-C motif chemokine 8; chemokine (C-C motif) ligand 8; HC14; MCP-2; MCP-2(6-76); MCP2; Monocyte chemoattractant protein 2; Monocyte chemotactic protein 2; SCYA10; SCYA8; small inducible cytokine subfamily A (Cys-Cys), member 8 (monocyte chemotactic protein 2); Small-inducible cytokine A8
Gene Aliases: CCL8; HC14; MCP-2; MCP2; SCYA10; SCYA8
UniProt ID: (Human) P80075
Entrez Gene ID: (Human) 6355