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          • Primary Antibodies ›
          • CCL2 (MCP-1) Antibodies

          Bioss

          MCP1 Polyclonal Antibody

          View all (65) CCL2 (MCP-1) antibodies

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          Cite MCP1 Polyclonal Antibody

          Additional Information:
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          MCP1 Polyclonal Antibody

          Product Details

          BS-1101R

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:2,000
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          1:200-1:400
          -

          Immunohistochemistry (Frozen) (IHC (F))

          1:100-1:500
          -

          Immunocytochemistry (ICC/IF)

          1:50-1:200
          -

          ELISA (ELISA)

          1:500-1:1,000
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          KLH conjugated synthetic peptide derived from rat MCP-1, amino acids 61-148.
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Purification

          Protein A

          Storage buffer

          0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

          Contains

          0.02% ProClin 300

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Target Information

          This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: C-C motif chemokine 2; chemokine (C-C motif) ligand 2; chemotactic and activating factor precursor; Genbank Staff Annotation: The small inducible cytokine A2 (SWISS-PROT ACC P13500) is encoded in this mRNA, although it is interrupted and partial, perhaps indicating that this CDS is not the true product of the gamma.1 gene.; H-MCP-1; HC11; immediate-early serum-responsive JE protein; Immediate-early serum-responsive protein JE; MCAF; MCP-1; MGC9434; Monocyte chemoattractant protein 1; monocyte chemoattractant protein-1; Monocyte chemotactic and activating factor; monocyte chemotactic protein; Monocyte chemotactic protein 1; Monocyte secretory protein JE; Mutations: 171:OK; Platelet-derived growth factor-inducible protein JE; RP23-350G1.3; small inducible cytokine A2; small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je); small inducible cytokine subfamily A (Cys-Cys), member 2; small inducible gene JE; Small-inducible cytokine A2; unnamed protein product

          View more View less

          Gene Aliases: AI323594; CCL2; GDCF-2; HC11; HSMCR30; JE; MCAF; MCP-1; MCP1; SCYA2; Sigje; SMC-CF

          View more View less

          UniProt ID: (Human) P13500, (Rat) P14844, (Mouse) P10148

          View more View less

          Entrez Gene ID: (Human) 6347, (Rat) 24770, (Mouse) 20296

          View more View less

          Function(s)
          protein kinase activity receptor binding cytokine activity protein binding chemokine activity CCR2 chemokine receptor binding chemoattractant activity CCR chemokine receptor binding G-protein coupled receptor binding heparin binding cytokine intercellular signal molecule
          Process(es)
          angiogenesis monocyte chemotaxis protein phosphorylation chemotaxis inflammatory response immune response humoral immune response cytoskeleton organization cell adhesion signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger JAK-STAT cascade regulation of cell shape response to bacterium organ morphogenesis positive regulation of gene expression positive regulation of macrophage chemotaxis viral genome replication cytokine-mediated signaling pathway sensory perception of pain cellular homeostasis positive regulation of cell migration negative regulation of glial cell apoptotic process helper T cell extravasation chemokine (C-C motif) ligand 2 signaling pathway negative regulation of neuron apoptotic process astrocyte cell migration cellular response to fibroblast growth factor stimulus eosinophil chemotaxis macrophage chemotaxis positive regulation of T cell activation positive chemotaxis positive regulation of synaptic transmission, glutamatergic antimicrobial humoral immune response mediated by antimicrobial peptide chemokine-mediated signaling pathway cellular response to lipopolysaccharide cellular response to interferon-gamma cellular response to interleukin-1 cellular response to tumor necrosis factor positive regulation of calcium ion import positive regulation of glutamate receptor signaling pathway negative regulation of vascular endothelial cell proliferation negative regulation of G1/S transition of mitotic cell cycle positive regulation of endothelial cell apoptotic process positive regulation of apoptotic cell clearance negative regulation of natural killer cell chemotaxis MAPK cascade response to hypoxia positive regulation of leukocyte mediated cytotoxicity positive regulation of endothelial cell proliferation leukocyte migration involved in inflammatory response positive regulation of leukocyte migration positive regulation of cellular extravasation cellular calcium ion homeostasis transforming growth factor beta receptor signaling pathway aging glial cell migration response to heat response to wounding response to mechanical stimulus response to gamma radiation regulation of vascular endothelial growth factor production response to activity negative regulation of angiogenesis positive regulation of cell-cell adhesion neutrophil chemotaxis organ regeneration lipopolysaccharide-mediated signaling pathway response to lipopolysaccharide response to progesterone positive regulation of tumor necrosis factor production cellular response to insulin stimulus positive regulation of collagen biosynthetic process response to vitamin B3 cellular response to drug cellular response to macrophage colony-stimulating factor stimulus cellular response to platelet-derived growth factor stimulus chemokinesis response to drug response to amino acid protein kinase B signaling response to ethanol positive regulation of cell adhesion response to antibiotic vascular endothelial growth factor receptor signaling pathway lymphocyte chemotaxis positive regulation of synaptic transmission response to glucocorticoid positive regulation of nitric-oxide synthase biosynthetic process maternal process involved in female pregnancy maternal process involved in parturition cellular response to retinoic acid cellular response to ATP cellular response to interleukin-6 cellular response to lipoprotein particle stimulus cellular response to high density lipoprotein particle stimulus cellular response to organic cyclic compound cellular response to dexamethasone stimulus positive regulation of monocyte chemotaxis positive regulation of immune complex clearance by monocytes and macrophages positive regulation of protein targeting to membrane monocyte homeostasis
          It has to be done as per old AB suggested Products section.

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