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Invitrogen
MCRS1 Polyclonal Antibody
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Product Details
PA5-97963
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Microspherule protein 1 protein (1-138AA)
Conjugate
Form
Liquid
Concentration
4 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homopolymer poly(G) and poly(U) (PubMed:16571602). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 58 kDa microspherule protein; cell cycle-regulated factor (78 kDa); Cell cycle-regulated factor p78; INO80 complex subunit J; INO80 complex subunit Q; MCRS2; Microspherule protein 1
Gene Aliases: ICP22BP; INO80Q; MCRS1; MCRS2; MSP58; P78
UniProt ID: (Human) Q96EZ8
Entrez Gene ID: (Human) 10445
telomere maintenance
regulation of DNA replication
DNA repair
regulation of DNA repair
DNA recombination
chromatin organization
chromatin remodeling
cellular response to DNA damage stimulus
positive regulation of macromolecule metabolic process
regulation of telomere maintenance
regulation of chromosome organization
protein modification process
positive regulation of DNA repair
positive regulation of transcription, DNA-templated
positive regulation of nucleobase-containing compound metabolic process
positive regulation of transcription from RNA polymerase II promoter
regulation of embryonic development
regulation of cell cycle
regulation of DNA strand elongation
negative regulation of telomere maintenance via telomere lengthening
positive regulation of telomere maintenance in response to DNA damage
positive regulation of protein localization to nucleolus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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