Bioss

MCSF Receptor Polyclonal Antibody

View all (75) CSF1R (CD115) antibodies

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Datasheet
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Datasheet
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MCSF Receptor Polyclonal Antibody

Product Details

BS-2755R

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:500
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

Flow Cytometry (Flow)

1:20-1:100
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human MCSF receptor, amino acids 201-300.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

CSF1R (FMS) is involved in the production, differentiation, and function of macrophages, and is implicated in promyelocytic leukemias. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. CSF1R is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in the gene encoding CSF1R have been associated with a predisposition to myeloid malignancy.Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and plays an important role in innate immunity and in inflammatory processes. The first intron of the CSF1R gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Mutations in the CSF1R gene have been associated with a predisposition to myeloid malignancy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: c-fms; CD115; CD115 antigen; CSF-1 receptor; CSF-1-R; CSFIR; EC 2.7.10.1; FMS proto-oncogene; kinase CSFR; macrophage colony stimulating factor I receptor; Macrophage colony-stimulating factor 1 receptor; McDonough feline sarcoma viral (v-fms) oncogene homolog; OTTHUMP00000224093; Proto-oncogene c-Fms; proto-oncogene fms

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Gene Aliases: AI323359; C-FMS; CD115; CSF-1-R; CSF-1R; CSF1R; Csfmr; CSFR; Fim-2; FIM2; FMS; HDLS; M-CSF-R; M-CSFR; mrfms

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UniProt ID: (Human) P07333, (Mouse) P09581

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Entrez Gene ID: (Human) 1436, (Mouse) 12978, (Rat) 307403

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Function(s)
macrophage colony-stimulating factor receptor activity ATP binding protein phosphatase binding cytokine binding protein homodimerization activity nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity protein binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups molecular_function transmembrane signal receptor
Process(es)
positive regulation of protein phosphorylation inflammatory response signal transduction transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development axon guidance skeletal muscle tissue development cell proliferation positive regulation of cell proliferation negative regulation of cell proliferation regulation of cell shape peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway olfactory bulb development forebrain neuron differentiation hemopoiesis monocyte differentiation macrophage differentiation osteoclast differentiation positive regulation of cell migration ruffle organization cellular response to macrophage colony-stimulating factor stimulus macrophage colony-stimulating factor signaling pathway positive regulation of tyrosine phosphorylation of Stat3 protein negative regulation of apoptotic process innate immune response regulation of bone resorption cell-cell junction maintenance positive regulation of osteoclast differentiation phosphatidylinositol metabolic process protein autophosphorylation phosphatidylinositol-mediated signaling mammary gland duct morphogenesis positive regulation of protein tyrosine kinase activity positive regulation of ERK1 and ERK2 cascade cellular response to cytokine stimulus positive regulation of protein serine/threonine kinase activity positive regulation of chemokine secretion positive regulation of cell motility regulation of actin cytoskeleton reorganization immune system process protein phosphorylation phosphorylation
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