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Invitrogen
MCT2 Polyclonal Antibody
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FIGURE: 1 / 1
MCT2 Antibody (PA5-120845) in WB
Western blot analysis of MCT2 in extracts of various cell lines. Samples were incubated with MCT2 Polyclonal antibody (Product # PA5-120845) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-120845
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 379-478 of human SLC16A7 (NP_0012575511)
Conjugate
Form
Liquid
Concentration
0.34 mg/mL
Amount
34 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive test controls include: DU145, HepG2, HL-60, 293T, rat brain. The target is usually found in the following locations: Cell membrane, Multi-pass membrane protein.
Immunogen sequence: TIVECGPVLL GPPLAGKLVD LTGEYKYMYM SCGAIVVAAS VWLLIGNAIN YRLLAKERKE ENARQKTRES EPLSKSKHSE DVNVKVSNAQ SVTSERETNI
Target Information
Tissues with few or no mitochondria, such as erythrocytes and tumor cells, depend largely on glycolysis to generate ATP. The major end products of glycolysis, pyruvate and lactate, must be eliminated from these cells to enable continued glycolytic flux and prevent toxic effects. H+/monocarboxylate transporters mediate the transport of lactate and pyruvate. Human MCT2 has a high affinity for the transport of pyruvate.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MCT 2; monocarboxylate transporter; Monocarboxylate transporter 2; solute carrier family 16 (monocarboxylate transporter), member 7; solute carrier family 16 (monocarboxylic acid transporters), member 7; Solute carrier family 16 member 7; solute carrier family 16, member 7 (monocarboxylic acid transporter 2); unnamed protein product
Gene Aliases: MCT2; SLC16A7
UniProt ID: (Human) O60669, (Rat) Q63344
Entrez Gene ID: (Human) 9194, (Rat) 29735
pyruvate secondary active transmembrane transporter activity
protein binding
monocarboxylic acid transmembrane transporter activity
lactate transmembrane transporter activity
symporter activity
secondary active monocarboxylate transmembrane transporter activity
transmembrane transporter activity
identical protein binding
pyruvate transmembrane transporter activity
transporter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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