Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).
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Protein Aliases: MCT 4; MGC138472; MGC138474; monocarboxylate transporter; monocarboxylate transporter 3; Monocarboxylate transporter 4; MOT4; solute carrier family 16 (monocarboxylate transporter), member 3; solute carrier family 16 (monocarboxylic acid transporters), member 3; Solute carrier family 16 member 3; solute carrier family 16, member 3 (monocarboxylic acid transporter 4)
Gene Aliases: MCT 3; MCT 4; MCT-3; MCT-4; MCT3; MCT4; SLC16A3
Molecular Function: transporter