Bioss

MDC1 Polyclonal Antibody

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MDC1 Antibody in ELISA (ELISA) — Antigen: bs-2400P, 0.2ug/100ul Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; Secondary: HRP conjugated Goat-Anti-Rabbit IgG(bs-0295G-HRP) at 1:5000; TMB staining; Read the data in Microplate Reader by 450nm.

Product Details

BS-2400R

Applications	Tested Dilution	Publications
Western Blot (WB)	1:300-1:1,000	-
Immunohistochemistry (Paraffin) (IHC (P))	1:200	-
Immunohistochemistry (Frozen) (IHC (F))	1:100-1:500	-
Immunocytochemistry (ICC/IF)	1:50-1:200	-
ELISA (ELISA)	1:5,000-1:10,000	-

Product Specifications
Species Reactivity	Human, Mouse, Rat
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	KLH conjugated synthetic peptide derived from human MDC1, amino acids 31-130. View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	1 mg/mL
Purification	Protein A
Storage buffer	PBS with 1% BSA, 50% glycerol
Contains	0.09% sodium azide
Storage conditions	-20°C

Target Information

MDC1 participates in the early response to DNA damage. It is thought to be a member of the BRCT (BRCA1 C-terminus) super family of nuclear proteins. It contains an N-terminus forkhead-associated (FHA) motif, two C-terminus BRCT motifs and 13 internal repetitions of a 41 amino acid sequence.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DAAP-285E11.7; DKFZp781A0122; homologue to Drosophila photoreceptor protein calphotin; mediation of DNA damage checkpoint 1; Mediator of DNA damage checkpoint protein 1; mediator of DNA-damage checkpoint 1; MGC166888; Nuclear factor with BRCT domains 1

Gene Aliases: 6820401C03; AA413496; KIAA0170; MDC1; mKIAA0170; NFBD1

UniProt ID: (Human) Q14676, (Mouse) Q5PSV9, (Rat) Q5U2M8

Entrez Gene ID: (Human) 9656, (Mouse) 240087, (Rat) 309595

Function(s)

DNA repair cellular response to DNA damage stimulus cell cycle double-strand break repair via nonhomologous end joining protein sumoylation intra-S DNA damage checkpoint biological_process

Process(es)

protein binding protein C-terminus binding FHA domain binding molecular_function