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Proteintech
ME1 Polyclonal Antibody
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Product Details
16619-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ME1 Fusion Protein Ag9916 (226-572 aa encoded by BC025246)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: DEFMEAVSS KYGMNCLIQF EDFANVNAFR LLNKYRNQYC TFNDDIQGTA SVAVAGLLAA LRITKNKLSD QTILFQGAGE AALGIAHLIV MALEKEGLPK EKAIKKIWLV DSKGLIVKGR ASLTQEKEKF AHEHEEMKNL EAIVQEIKPT ALIGVAAIGG AFSEQILKDM AAFNERPIIF ALSNPTSKAE CSAEQCYKIT KGRAIFASGS PFDPVTLPNG QTLYPGQGNN SYVFPGVALG VVACGLRQIT DNIFLTTAEV IAQQVSDKHL EEGRLYPPLN TIRDVSLKIA EKIVKDAYQE KTATVYPEPQ NKEAFVRSQM YSTDYDQILP DCYSWPEEVQ KIQTKVDQ (226-572 aa encoded by BC025246)
Target Information
ME1 encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cytosolic malic enzyme 1; malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)); malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+); Malic enzyme 1; malic enzyme 1, NADP(+)-dependent, cytosolic; malic enzyme 1, soluble; Malic enzyme, cytoplasmic; malic enzyme, supernatant; NADP-dependent malic enzyme; NADP-ME; pyruvic-malic carboxylase; unnamed protein product
Gene Aliases: D9Ertd267e; HUMNDME; Mdh-1; ME1; MES; Mod-1; MOD1
UniProt ID: (Human) P48163, (Mouse) P06801
Entrez Gene ID: (Human) 4199, (Mouse) 17436, (Rat) 24552
magnesium ion binding
malic enzyme activity
malate dehydrogenase (decarboxylating) (NADP+) activity
protein binding
oxaloacetate decarboxylase activity
electron carrier activity
oxidoreductase activity
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
manganese ion binding
identical protein binding
ADP binding
metal ion binding
NADP binding
NAD binding
malate dehydrogenase (decarboxylating) (NAD+) activity
oxidoreductase
carbohydrate metabolic process
pyruvate metabolic process
malate metabolic process
NADP metabolic process
nucleotide biosynthetic process
response to hormone
response to carbohydrate
NAD metabolic process
protein homotetramerization
regulation of NADP metabolic process
protein tetramerization
oxidation-reduction process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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