Peptide sequence: QQLNIHGLLP PSFNSQEIQV LRVVKNFEHL NSDFDRYLLL MDLQDRNEKL
Sequence homology: Cow: 92%; Dog: 85%; Horse: 92%; Human: 100%; Mouse: 100%; Pig: 91%; Rabbit: 100%; Rat: 100%; Sheep: 92%
ME1 encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet.
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Protein Aliases: malate dehydrogenase; malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)); Malic enzyme 1; malic enzyme 1, NADP(+)-dependent, cytosolic; malic enzyme 1, soluble; Malic enzyme, cytoplasmic; NADP-dependent malic enzyme; NADP-ME; pyruvic-malic carboxylase
Gene Aliases: HUMNDME; ME1; MES
UniProt ID: (Human) P48163
Entrez Gene ID: (Human) 4199
Molecular Function: oxidoreductase