This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: KVISKPISEH KILFLGAGEA ALGIANLIVM SMVENGLSEQ EAQKKIWMFD KYGLLVKGRK AKIDSYQEPF THSAPESIPD TFEDAVNILK PSTIIGVAGA GRLFTPDVIR AMASINERPV IFALSNPTA
Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 80%.
ME2 encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: malate dehydrogenase; malate dehydrogenase (oxaloacetate-decarboxylating); Malic enzyme 2; malic enzyme 2, NAD(+)-dependent, mitochondrial; NAD-dependent malic enzyme, mitochondrial; NAD-ME; pyruvic-malic carboxylase
Gene Aliases: ME2; ODS1
UniProt ID: (Human) P23368
Entrez Gene ID: (Human) 4200
Molecular Function: oxidoreductase