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Invitrogen
MECOM Polyclonal Antibody
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Product Details
PA5-115607
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human MECOM(Accession Q03112), corresponding to amino acid residues I100-Y150.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total Myelodysplasia Syndrome 1.
Target Information
The MECOM gene (MDS1 and EVI1 Complex Locus) is located on chromosome 3q26.2 and encodes a protein involved in transcriptional regulation. This gene produces multiple transcript variants encoding different isoforms, including MDS1, EVI1, and PRDM3. The EVI1 protein, one of the main isoforms, is characterized by zinc finger motifs, which facilitate DNA binding, and a SET domain responsible for methyltransferase activity. MECOM plays a crucial role in cell proliferation, differentiation, apoptosis, and hematopoiesis. Aberrations in MECOM, particularly overexpression or rearrangements, are associated with various hematological malignancies, including acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). The MECOM gene's normal function and pathological alterations make it a significant target for research in cancer biology and therapeutics.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AML1-EVI-1 fusion protein; Ecotropic virus integration site 1 protein homolog; EVI-1; Histone-lysine N-methyltransferase MECOM; MDS1; MDS1 and EVI1 complex locus protein; MDS1 and EVI1 complex locus protein EVI1; MDS1 and EVI1 complex locus protein MDS1; Myelodysplasia syndrome 1 protein; Myelodysplasia syndrome-associated protein 1; oncogene EVI1; PR domain 3; unnamed protein product; zinc finger protein Evi1
Gene Aliases: AML1-EVI-1; EVI1; KMT8E; MDS1; MDS1-EVI1; MECOM; PRDM3; RUSAT2
UniProt ID: (Human) Q03112
Entrez Gene ID: (Human) 2122
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
methyltransferase activity
zinc ion binding
transferase activity
protein homodimerization activity
metal ion binding
histone methyltransferase activity (H3-K9 specific)
histone H3 methyltransferase activity
histone H3K9me2 methyltransferase activity
histone H3K9 monomethyltransferase activity
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
apoptotic process
cell differentiation
negative regulation of transforming growth factor beta receptor signaling pathway
methylation
negative regulation of programmed cell death
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of JNK cascade
regulation of cell cycle
heterochromatin organization
hematopoietic stem cell proliferation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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