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Immunogen sequence: MAEKFDHLEEH LEKFVENIRQ LGIIVSDFQP SSQAGLNQKL NFIVTGLQDI DKCRQQLHDI TVP
Highest antigen sequence identity to the following orthologs - mouse 98%, rat 98%.
MED10 is a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Mediator complex subunit 10; Mediator of RNA polymerase II transcription subunit 10; mediator of RNA polymerase II transcription, subunit 10; Transformation-related gene 17 protein; Transformation-related gene 20 protein; TRG-17; TRG-20
Gene Aliases: L6; MED10; NUT2; TRG17; TRG20
UniProt ID: (Human) Q9BTT4
Entrez Gene ID: (Human) 84246
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