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This gene encodes a transcription factor that represses GATA-regulated genes and binds to a dynein light chain protein. Binding of the encoded protein to the dynein light chain protein affects binding to GATA consensus sequences and suppresses its transcriptional activity. Defects in this gene are a cause of tricho-rhino-phalangeal syndrome (TRPS) types I-III.
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Protein Aliases: Activator-recruited cofactor 105 kDa component; activator-recruited cofactor, 105-kD; ARC105; CTG repeat protein 7a; DKFZp686A2214; DKFZp762B1216; FLJ42282; FLJ42935; Mediator complex subunit 15; Mediator of RNA polymerase II transcription subunit 15; PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein; PC2 glutamine/Q-rich-associated protein; PC2-glutamine-rich-associated protein; Positive cofactor 2 glutamine/Q-rich-associated protein; positive cofactor 2, glutamine/Q-rich-associated protein; TIG-1; TPA inducible gene-1; TPA inducible protein; TPA-inducible gene 1 protein; trinucleotide repeat containing 7; Trinucleotide repeat-containing gene 7 protein
Gene Aliases: ARC105; CAG7A; CTG7A; MED15; PCQAP; TIG-1; TIG1; TNRC7
UniProt ID: (Human) Q96RN5
Entrez Gene ID: (Human) 51586
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