Immunogen sequence: RARRSMDRAG APWHLRYLGQ PEMGDKNRHA LVRNCVDIAT SENLTDFLME MGFRMDHEFV AKGH
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
Zinc, an essential element required for cell proliferation and differentiation, plays a role in a diverse array of cellular functions, including acting as a cofactor for numerous enzymes and transcription factors and as a neuroregulator. The zinc transporter (ZnT) family regulates the supply of zinc within cells, and its members are characterized by containing six membrane-spanning domains, a large histidine-rich intracellular loop, and a C-terminal tail. ZnT-1, a ubiquitous protein of approximately 60 kDa, localizes to the plasma membrane to aid in the export of zinc out of cells.
Protein Aliases: FLJ20045; mediator 18; Mediator complex subunit 18; Mediator of RNA polymerase II transcription subunit 18; mediator of RNA polymerase II transcription, subunit 18 homolog; p28b; TRAP/mediator complex subunit p28b
Gene Aliases: MED18; p28b
UniProt ID: (Human) Q9BUE0
Entrez Gene ID: (Human) 54797