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Immunogen sequence: VIIPLVLSPD RDEDLMRQTE GRVPVFSHEV VPDHLRTKPD PEVEEQEKQL TTDAARIGAD AAQKQ
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 32%.
This gene encodes a protein that is one of more than 20 subunits of the mediator complex, first identified in S. cerevisiae, that is required for activation of transcription. The product of this gene also interacts with elongins B and C, and CUL2 and RBX1, to reconstitute a ubiquitin ligase. Two alternative transcripts encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Activator-recruited cofactor 32 kDa component; ARC32; Mediator complex subunit 8; Mediator of RNA polymerase II transcription subunit 8; mediator of RNA polymerase II transcription subunit MED8; mediator of RNA polymerase II transcription, subunit 8 homolog; MGC17544; MGC19641
Gene Aliases: 2210021A15Rik; AB041805; ARC32; MED8; MNCb-2386
UniProt ID: (Human) Q96G25, (Mouse) Q9D7W5
Entrez Gene ID: (Human) 112950, (Mouse) 80509, (Rat) 362575
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