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          • Primary Antibodies ›
          • MEF2B Antibodies

          Bioss

          MEF2B Polyclonal Antibody

          View all (13) MEF2B antibodies

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          Cite MEF2B Polyclonal Antibody

          Additional Information:
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          Product Details

          BS-9470R

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:2,000
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          1:100-1:500
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          KLH conjugated synthetic peptide derived from human MEF2B.

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Purification

          Protein A

          Storage buffer

          0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

          Contains

          0.02% ProClin 300

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Target Information

          The myocyte enhancer factor-2 (MEF-2) family of transcription factors associated with co-repessors or co-activators to regulate development and function of T cells, neuronal cells and muscle cells. Four family members arise from alternatively spliced transcripts, termed MEF-2A, -2B, -2C and -2D. These members bind as homo- and heterodimers to the MEF-2 site in the promoter region of affected genes. Differential regulation in the expression of the four transcripts implies functional distinction for each during embryogenesis and development. The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: LOC729991-MEF2B; MADS box transcription enhancer factor 2, polypeptide B (myocyte enhancer factor 2B); MEF2BNB-MEF2B; Myocyte-specific enhancer factor 2B; RSRFR2; Serum response factor-like protein 2; unnamed protein product

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          Gene Aliases: AI451606; MEF2B; RSRFR2; XMEF2

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          UniProt ID: (Human) Q02080

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          Entrez Gene ID: (Human) 100271849, (Mouse) 17259, (Rat) 498607

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          Function(s)
          RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding histone deacetylase binding protein dimerization activity sequence-specific double-stranded DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding MADS box transcription factor
          Process(es)
          heart development muscle organ development cell differentiation positive regulation of transcription from RNA polymerase II promoter animal organ development regulation of transcription, DNA-templated transcription from RNA polymerase II promoter transcription, DNA-templated
          It has to be done as per old AB suggested Products section.

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