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This antibody is a rabbit polyclonal antibody raised against an internal 161Aa region of human MEF2C. Phosphorylation and acetylation may affect the molecular weight of protein, and 60-70 kDa was also been reported.
Immunogen sequence: PSLQRNSMS PGVTHRPPSA GNTGGLMGGD LTSGAGTSAG NGYGNPRNSP GLLVSPGNLN KNMQAKSPPP MNLGMNNRKP DLRVLIPPGS KNTMPSVSED VDLLLNQRIN NSQSAQSLAT PVVSVATPTL PGQGMGGYPS AISTTYGTEY SLSSADLSSL SGF (176-336 aa encoded by BC026341)
MEF2C is a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B cells. May also be involved in neurogenesis and in the development of cortical architecture. Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: MADS box transcription enhancer factor 2, polypeptide C; Myocyte enhancer factor 2C; Myocyte-specific enhancer factor 2C
Gene Aliases: 5430401D19Rik; 9930028G15Rik; AV011172; C5DELq14.3; DEL5q14.3; Mef2; MEF2C; RGD1563119
Molecular Function: MADS box transcription factor