Peptide sequence: GDGLSSPAGG SYETGDRDDG RGDFGPTLGL LRPAPEPEAE GSAVKRMRLD
Sequence homology: Cow: 100%; Dog: 86%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%
This gene is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by class II histone deacetylases. Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in leukemogenesis. The encoded protein may also be involved in Parkinson disease and myotonic dystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012].
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Protein Aliases: DKFZp686I1536; MADS box transcription enhancer factor 2, polypeptide D; Myocyte enhancer factor 2D; myocyte enhancer factor 2D-like; Myocyte-specific enhancer factor 2D
Gene Aliases: BOS_2847; C80750; MEF2D