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Invitrogen
MEFV Polyclonal Antibody
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Product Details
PA5-115811
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human MEFV(Accession O15553), corresponding to amino acid residues S104-S154.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total Pyrin.
Target Information
This gene encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity. Mutations in this gene are associated with Mediterranean fever, a hereditary periodic fever syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HGNC:6998; Marenostrin; MGC126560; MGC126586; Pyrin
Gene Aliases: FMF; MEF; MEFV; TRIM20
UniProt ID: (Human) O15553
Entrez Gene ID: (Human) 4210
inflammatory response
positive regulation of autophagy
negative regulation of interleukin-1 beta production
negative regulation of interleukin-12 production
response to interferon-gamma
negative regulation of inflammatory response
negative regulation of macrophage inflammatory protein 1 alpha production
negative regulation of cytokine production involved in inflammatory response
negative regulation of NLRP3 inflammasome complex assembly
positive regulation of cysteine-type endopeptidase activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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