Search
Proteintech
MEFV Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
24280-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MEFV Fusion Protein Ag18000 (1-350 aa encoded by BC101511)
Conjugate
Form
Liquid
Concentration
0.49 mg/mL
Amount
73.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAKTPSDHL LSTLEELVPY DFEKFKFKLQ NTSVQKEHSR IPRSQIQRAR PVKMATLLVT YYGEEYAVQL TLQVLRAINQ RLLAEELHRA AIQEYSTQEN GTDDSAASSS LGENKPRSLK TPDHPEGNEG NGPRPYGGGA ASLRCSQPEA GRGLSRKPLS KRREKASEGL DAQGKPRTRS PALPGGRSPG PCRALEGGQA EVQLRRNASS AGRLQGLAGG APGQKECRPF EVYLPSGKMR PRSLEVTIST GEKAPANPEI LLTLEEKTAA NLDSATEPRA RPTPDGGASA DLKEGPGNPE HSVTGRPPDT AASPRCHAQE GDPVDGTCVR DSCSFPEAVS GHPQASGSRS P (1-350 aa encoded by BC101511)
Target Information
This gene encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity. Mutations in this gene are associated with Mediterranean fever, a hereditary periodic fever syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HGNC:6998; Marenostrin; Mediterranean fever; MEFV innate immuity regulator, pyrin; MEFV, pyrin innate immunity regulator; MGC126560; MGC126586; Pyrin; unnamed protein product
Gene Aliases: FMF; MEF; MEFV; PAAND; TRIM20
UniProt ID: (Human) O15553
Entrez Gene ID: (Human) 4210
pattern recognition receptor signaling pathway
immune system process
inflammatory response
regulation of gene expression
positive regulation of autophagy
regulation of interleukin-1 beta production
negative regulation of interleukin-1 beta production
negative regulation of interleukin-12 production
positive regulation of interleukin-1 beta production
response to interferon-gamma
innate immune response
regulation of inflammatory response
negative regulation of inflammatory response
positive regulation of inflammatory response
response to other organism
pyroptosis
negative regulation of macrophage inflammatory protein 1 alpha production
negative regulation of cytokine production involved in inflammatory response
negative regulation of NLRP3 inflammasome complex assembly
pyroptosome complex assembly
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support