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Proteintech
MEI1 Polyclonal Antibody
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Product Details
13456-1-AP
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MEI1 Fusion Protein Ag4253 (1-238 aa encoded by BC032248)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Amount
40.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody recognizes isoform 1, 2, 3, 5, and 7 of MEI1 gene with MW 141 kDa, 67-72 kDa, 49-54 kDa, and 26 kDa.
Immunogen sequence: MLALTLAKA DSPRTALLCS AWLLTASFSA QQHKGSLQVH QTLSVEMDQV LKALSFPKKK AALLSAAILC FLRTALRQSF SSALVALVPS GAQPLPATKD TVLAPLRMSQ VRSLVIGLQN LLVQKDPLLS QACVGCLEAL LDYLDARSPD IALHVASQPW NRFLLFTLLD AGENSFLRPE ILRLMTLLQS MGHLADHSMA QTLQASLEGL PPSTSSGQPP LQDMLCLGGV AVSLSHIRN (1-238 aa encoded by BC032248 )
Target Information
The predominant cause of spermatogenic arrest of meiosis is the failure of homologous chromosomes to accurately synapse. MEI1 (Meiosis inhibitor protein 1), also designated Meiosis defective protein 1, is a 1274 amino acid protein that is likely required for the formation of genetically programmed double-strand breaks, the first step in the initiation of meiosis. With predominant expression in testis, it is likely that defects of the gene encoding MEI1 results in male infertility. Interestingly, studies show that genetic variation in the MEI gene possibly predisposes European Americans but not Israeli men to infertility by meiotic arrest. Human MEI1 shares 79% sequence similarity with its mouse homolog. There are seven isoforms of MEI1 that are produced as a result of alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: mei1; MEI1(Long); MEI1(Short); meiosis defective 1; Meiosis defective protein 1; meiosis inhibitor 1; Meiosis inhibitor protein 1; spermatogenesis associated 38; unnamed protein product
Gene Aliases: 4932408F18Rik; HYDM3; MEI1; SPATA38
UniProt ID: (Human) Q5TIA1, (Mouse) Q9D4I2
Entrez Gene ID: (Human) 150365, (Rat) 315162, (Mouse) 74369
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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