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MEIS1 + MEIS2 Polyclonal Antibody
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Product Details
BS-11885R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat,
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human MEIS2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
MEIS1 acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias. MEIS2 is involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription; isoform 5 cannot activate DRD1 transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2; Homeobox protein Meis1; Homeobox protein Meis2; leukemogenic homolog protein; Meis homolog 2; Meis1, myeloid ecotropic viral integration site 1 homolog; Meis1, myeloid ecotropic viral integration site 1 homolog 2; Meis1-related gene 1; Meis1-related protein 1; Meis2 homeobox; Myeloid ecotropic viral integration site 1; myeloid ecotropic viral integration site-related gene 1; TALE homeobox protein Meis2; unnamed protein product; WUGSC:H_NH0444B04.1
Gene Aliases: A430109D20Rik; C530044H18Rik; CPCMR; Evi8; HsT18361; MEIS1; MEIS2; MRG1; Stra10
UniProt ID: (Human) O00470, (Human) O14770, (Mouse) Q60954, (Mouse) P97367
Entrez Gene ID: (Human) 4211, (Human) 4212, (Rat) 686117, (Mouse) 17268, (Mouse) 17536, (Rat) 311311
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
protein binding
sequence-specific DNA binding
transcription factor binding
sequence-specific double-stranded DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein heterodimerization activity
transcription cofactor activity
molecular_function
homeodomain transcription factor
angiogenesis
eye development
lens morphogenesis in camera-type eye
regulation of transcription, DNA-templated
brain development
locomotory behavior
positive regulation of cell proliferation
embryonic pattern specification
organ morphogenesis
hemopoiesis
megakaryocyte development
negative regulation of myeloid cell differentiation
negative regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
blood vessel morphogenesis
definitive hemopoiesis
cell growth involved in cardiac muscle cell development
negative regulation of transcription from RNA polymerase II promoter
visual learning
response to mechanical stimulus
pancreas development
positive regulation of mitotic cell cycle
response to growth factor
positive regulation of cardiac muscle myoblast proliferation
transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
multicellular organism development
regulation of nucleic acid-templated transcription
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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