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MEK1/2 Polyclonal Antibody, CoraLite® Plus 488

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MEK1/2 Polyclonal Antibody, CoraLite® Plus 488

Product Details

CL488-11049

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1:50-1:500
-

Flow Cytometry (Flow)

0.80 µg/10^6 cells in a 100 µL suspension
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

MEK1/2 fusion protein Ag1481
3D Epitope / Immunogen

Conjugate

CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

Excitation/Emission Max

493/522 nm

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.5% BSA

Contains

0.05% ProClin 300

Storage conditions

-20°C, store in dark

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: MLARRKPVL PALTINPTIA EGPSPTSEGA SEANLVDLQK KLEELELDEQ QKKRLEAFLT QKAKVGELKD DDFERISELG AGNGGVVTKV QHRPSGLIMA RKLIHLEIKP AIRNQIIREL QVLHECNSPY IVGFYGAFYS DGEISICMEH MDGGSLDQVL KEAKRIPEEI LGKVSIAVLR GLAYLREKHQ IMHRDVKPSN ILVNSRGEIK LCDFGVSGQL IDSMANSFVG TRSYMAPERL QGTHYSVQSD IWSMGLSLVE LAVGRYPIPP PDAKELEAIF GRPVVDGEEG EPHSISPRPR PPGRPVSGHG MDSRPAMAIF ELLDYIVNEP PPKLPNGVFT PDFQEFVNKC LIKNPAERAD LKMLTNHTFI KRSEVEEVDF AGWLCKTLRL NQPGTPTRTA V

Target Information

MEK 1 (MAP Kinase Kinase, also known as MKK) is an integral component of the MAP kinase cascade that regulates cell growth and differentiation (Ahn, 1993; Chong et al., 2003). In brain, this pathway also plays a key role in synaptic (Adams and Sweatt, 2002). Activated MEK 1 acts as a dual specificity kinase phosphorylating both a threonine and a tyrosine residue on MAP kinase (Kyriakis et al., 1991; Seger et al., 1991; Crews et al., 1992).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Dual specificity mitogen-activated protein kinase kinase 1; Dual specificity mitogen-activated protein kinase kinase 2; EC 2.7.12.2; ERK activator kinase 1; ERK activator kinase 2; kinase MEK1; MAP kinase kinase 1; MAP kinase kinase 2; MAP kinase/Erk kinase; MAPK/ERK kinase 1; MAPK/ERK kinase 2; MAPKK 1; MAPKK 2; MEK 1; MEK 2; MEK-1; MEK-2; mitogen activated protein kinase kinase 1; mitogen activated protein kinase kinase 2; mitogen-activated protein kinase kinase 2, p45; MP2K1; protein kinase, mitogen activated, kinase 1, p45; protein kinase, mitogen activated, kinase 2, p45; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1); unnamed protein product

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Gene Aliases: AA589381; CFC3; CFC4; MAP2K1; MAP2K2; MAPKK1; MAPKK2; MEK1; MEK2; MEKK1; MEL; MK2; MKK1; MKK2; PRKMK1; PRKMK2

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UniProt ID: (Human) Q02750, (Human) P36507, (Mouse) P31938, (Mouse) Q63932

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Entrez Gene ID: (Human) 5604, (Human) 5605, (Mouse) 26395, (Mouse) 26396

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity MAP kinase kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity MAP-kinase scaffold activity protein binding ATP binding kinase activity transferase activity protein kinase binding protein kinase activator activity small GTPase binding mitogen-activated protein kinase kinase kinase binding protein serine/threonine kinase activator activity macromolecular complex binding scaffold protein binding protein serine kinase activity PDZ domain binding metal ion binding binding, bridging receptor signaling protein tyrosine phosphatase activity protein C-terminus binding transferase activity, transferring phosphorus-containing groups Ras GTPase binding protein N-terminus binding protein complex scaffold non-receptor serine/threonine protein kinase
Process(es)
MAPK cascade regulation of vascular smooth muscle contraction chemotaxis response to oxidative stress signal transduction heart development negative regulation of cell proliferation positive regulation of autophagy positive regulation of gene expression negative regulation of gene expression Schwann cell development cerebellar cortex formation central nervous system neuron differentiation neuron differentiation keratinocyte differentiation positive regulation of cell migration thyroid gland development melanosome transport regulation of stress-activated MAPK cascade positive regulation of transcription elongation from RNA polymerase II promoter negative regulation of homotypic cell-cell adhesion endodermal cell differentiation ERBB2-ERBB3 signaling pathway myelination positive regulation of MAPK cascade type B pancreatic cell proliferation positive regulation of transcription, DNA-templated positive regulation of muscle contraction positive regulation of Ras protein signal transduction vesicle transport along microtubule insulin-like growth factor receptor signaling pathway Golgi inheritance thymus development response to axon injury regulation of axon regeneration neuron projection morphogenesis cell motility positive regulation of axonogenesis response to glucocorticoid Bergmann glial cell differentiation face development lung morphogenesis trachea formation epithelial cell proliferation involved in lung morphogenesis placenta blood vessel development labyrinthine layer development triglyceride homeostasis ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade positive regulation of protein serine/threonine kinase activity regulation of Golgi inheritance cellular senescence regulation of neurotransmitter receptor localization to postsynaptic specialization membrane positive regulation of endodermal cell differentiation negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway regulation of early endosome to late endosome transport positive regulation of ATP biosynthetic process peptidyl-serine autophosphorylation positive regulation of cell motility activation of MAPK activity regulation of protein phosphorylation protein phosphorylation cell cycle arrest mitotic nuclear division cell proliferation phosphorylation peptidyl-tyrosine dephosphorylation positive regulation of GTPase activity positive regulation of cell differentiation protein heterooligomerization mitophagy in response to mitochondrial depolarization
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