This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Mouse MEK1/MAP2K1/MKK1.
MAP kinase kinase 1 (Mek 1), also known as mitogen activated protein kinase kinase, MAP kinase kinase, ERK kinase 1 or microtubule-associated protein 2 kinase, is a 43 kDa dual-specificity protein kinase that phosphorylates threonine and tyrosine residues on MAP kinases such as Erk 1 and 2. Phosphorylation by Mek1 increases Erk's ability to phosphorylate microtubule-associated proteins and myelin basic proteins. Mek 1 is involved in a diverse array of cellular processes such as stress-activated response, apoptosis, cytokine-induced cell proliferation, and DNA recombination during meiosis. Mek 1 is activated by phosphorylation on serine 218 and 222 by serine-threonine kinase, Raf-1, which is part of the p21ras signal transduction pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Dual specificity mitogen-activated protein kinase kinase 1; ERK activator kinase 1; MAP kinase kinase 1; MAPK/ERK kinase 1; MAPKK 1; MAPKK1; MEK 1; mitogen activated protein kinase kinase 1; MKK1; PRKMK1; protein kinase, mitogen activated, kinase 1, p45
Gene Aliases: Map2k1; MAPKK1; Mek1; MEKK1; Prkmk1
UniProt ID: (Mouse) P31938
Entrez Gene ID: (Mouse) 26395