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Proteintech
MEK3 Polyclonal Antibody
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Product Details
13898-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
MEK3 Fusion Protein Ag4861 (1-347 aa encoded by BC032478)
Conjugate
Form
Liquid
Concentration
0.42 mg/mL
Amount
63 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MESPASSQP ASMPQSKGKS KRKKDLRISC MSKPPAPNPT PPRNLDSRTF ITIGDRNFEV EADDLVTISE LGRGAYGVVE KVRHAQSGTI MAVKRIRATV NSQEQKRLLM DLDINMRTVD CFYTVTFYGA LFREGDVWIC MELMDTSLDK FYRKVLDKNM TIPEDILGEI AVSIVRALEH LHSKLSVIHR DVKPSNVLIN KEGHVKMCDF GISGYLVDSV AKTMDAGCKP YMAPERINPE LNQKGYNVKS DVWSLGITMI EMAILRFPYE SWGTPFQQLK QVVEEPSPQL PADRFSPEFV DFTAQCLRKN PAERMSYLEL MEHPFFTLHK TKKTDIAAFV KEILGEDS (1-347 aa encoded by BC032478)
Target Information
MAP2K3 (MEK3) is a dual-specificity protein kinase which acts in cellular signal transduction pathways, and is necessary for the expression of glucose transporter. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for MEK3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Dual specificity mitogen-activated protein kinase kinase 3; EC 2.7.12.2; MAP kinase kinase 3; MAP2K3; MAPK/ERK kinase 3; MAPKK 3; MEK 3; mitogen activated protein kinase kinase 3; protein kinase, mitogen-activated, kinase 3; SAPK kinase 2; Stress-activated protein kinase kinase 2; unnamed protein product
Gene Aliases: AW212142; MAP2K3; MAPKK3; MEK3; MKK3; mMKK3b; PRKMK3; SAPKK-2; SAPKK2; SKK2
UniProt ID: (Human) P46734, (Mouse) O09110
Entrez Gene ID: (Human) 5606, (Mouse) 26397, (Rat) 303200
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase activity
protein tyrosine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
protein kinase binding
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
MAPK cascade
regulation of cytokine production
response to ischemia
inflammatory response
signal transduction
heart development
stress-activated protein kinase signaling cascade
negative regulation of hippo signaling
cellular response to vascular endothelial growth factor stimulus
p38MAPK cascade
positive regulation of MAPK cascade
positive regulation of blood vessel endothelial cell migration
positive regulation of protein kinase activity
positive regulation of transcription, DNA-templated
protein maturation
cardiac muscle contraction
pyroptosis
cellular response to lipopolysaccharide
cellular response to UV-B
cellular response to sorbitol
cellular senescence
regulation of intracellular signal transduction
NLRP1 inflammasome complex assembly
activation of MAPK activity
protein phosphorylation
regulation of mitotic cell cycle
phosphorylation
regulation of cytokine biosynthetic process
regulation of apoptotic process
positive regulation of protein phosphorylation
positive regulation of nitric-oxide synthase biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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